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Lipid is formed by Two convergent pathways for triacylglycerol biosynthesis. The stepwise acylation of glycerol through the two pathways for triacylglycerol synthesis are shown. Abbreviations: fatty acid (FA), glycerol-3-phosphate (G-3-P), G-3-P acyltransferase (GPAT), lysophosphatidic acid (LPA), acylglycerol-3-phosphate acyltransferase (AGPAT), phosphatidic acid (PA), monoacylglycerol (MAG), MAG acyltransferase (MGAT), diacylglycerol (DAG), DAG acyltransferase (DGAT), and triacylglycerol (TAG). Acyl-CoA: monoacylglycerol acyltransferase (MGAT) Acyl-CoA: monoacylglycerol acyltransferase (MGAT) catalyzes the synthesis of diacylglycerols from monoacylglycerols and long chain fatty acyl-CoAs, a first step in the monoacylglycerol pathway that is major route of triacylglycerol synthesis. This pathway contributes more than 80% of glycerolipid synthesis in the intestinal mucosa. MGAT isoforms and expression MGAT 1 Mouse MGAT-1, identified by ...
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