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Showing posts with the label Lipid

Key Enzyme of Lipid Formation

 Lipid is formed by  Two convergent pathways for triacylglycerol biosynthesis. The stepwise acylation of glycerol through the two pathways for triacylglycerol synthesis are shown. Abbreviations: fatty acid (FA), glycerol-3-phosphate (G-3-P), G-3-P acyltransferase (GPAT), lysophosphatidic acid (LPA), acylglycerol-3-phosphate acyltransferase (AGPAT), phosphatidic acid (PA), monoacylglycerol (MAG), MAG acyltransferase (MGAT), diacylglycerol (DAG), DAG acyltransferase (DGAT), and triacylglycerol (TAG). Acyl-CoA: monoacylglycerol acyltransferase (MGAT)  Acyl-CoA: monoacylglycerol acyltransferase (MGAT) catalyzes the synthesis of  diacylglycerols from monoacylglycerols and long chain fatty acyl-CoAs, a first step  in the monoacylglycerol pathway that is major route of triacylglycerol synthesis. This   pathway contributes more than 80% of glycerolipid synthesis in the intestinal mucosa. MGAT isoforms and expression MGAT 1 Mouse MGAT-1, identified by ...