Donwload Design, Synthesis and Docking study of N-substituted 2,4- Thiazolidinedione as Cytotoxic Agents
SUMMARY Download Design, Synthesis and Docking study of N-substituted 2,4- Thiazolidinedione as Cytotoxic Agents · Introduction about anticancer agents have been studied. · Chemistry and biological importance of 2,4-thiazolidinedione have also been studied. · Various literatures regarding N-substituted 2,4-thiazolidinedione with biological activity have been reviewed. · Docking study on the ERK2 receptor has been done by AUTODOCK 4.2 software. And 132 compounds were predicted. · Different 8 good docking scoring N-substituted 5-arylidine 2,4-thiazolidinedione derivatives have been synthesized. · All the synthesized compounds were characterized by IR, Mass and 1H NMR spectro...